Acetaminophen versus Fentanyl for PostOperative Pain after Lower Limb Surgery: A Randomized Controlled Trial
BACKGROUND: Opioids for pain management are associated with a number of adverse effects and consequently their use should be avoided. The aim of this study was to compare the analgesic effect of acetaminophen and fentanyl in the management of postoperative pain in patients following intra-medullary nail fixation.
METHODS: 114 male patients between the ages of 25 and 50 years who underwent intra-medullary nail fixation in Poursina university hospital of Rasht between 2012 and 2013 enrolled in this double-blinded randomized controlled trial study. The trial registration was IRCT 2012122611898N1. After completion of the surgery, patients were taken to the recovery room and were randomly allocated to one of the two groups. One group received intravenous acetaminophen, 1000 mg in 150 mL normal saline in 15 min every 6 hours for 24 hours. Another group received fentanyl as patient controlled analgesia, for 24 hours. Patients were evaluated by visual analogue score (VAS) and pain relief rating (PR) at 0, 15, 30 and 45 minutes, 1, 2, 3, 4 and 5 hours after elimination of intraoperative analgesic effect.
RESULTS: Of 103 patients, 47 were randomized to receive fentanyl and 56 were randomized to receive acetaminophen. The mean age of subjects was 38.7±1.1. The VAS scores were significantly higher (p <0.05) in patients randomized to receive fentanyl at 30 minutes, 45 minutes, 1 hour, 3 and 4 hours.
CONCLUSION: Intravenous acetaminophen is an effective analgesic agent and may be preferable to fentanyl for postoperative pain management in orthopedic setting.