Malignancy of nasal cavity and paranasal sinuses are considered to be rare accounting for less than 1% of all malignancies and 3% of head and neck cancers. Primary squamous cell carcinoma of nasal septum is deemed to be extremely rare. The published series and case report have been too few to allow existence of its own staging system. Further, because of its rarity, the disease is often misdiagnosed as its symptoms are similar to everyday nasal symptoms. We report a case of a 40-year-old woman who was complaining of blocked nasal passage and epistaxis for 5 years and squamous cell carcinoma was found on biopsy.