Determine The Role of Locoregionally Advanced Oral Cancer (LAOC) Neoadjuvant Chemotherapy(NACT)

Background: Oral cancer (OC) ranks as the sixth most prevalent kind of cancer in the United States, according to researchers. According to many studies, the head and neck account for 40% of all cancer cases in India. Low rates of survival after surgery and postoperative irradiation (PORT) for advanced malignancies have prompted researchers to consider NACT as a viable treatment option. Objectives: To evaluate the role of NACT in LAOC. Methodology: We gathered demographic data, clinical history, prior medical history, family history, and social history using standard, semi-structured questionnaires and required investigations in 40 patients using a prospective analytical type of research. All patients received NACT and were followed for six months. Result and Conclusion. We found that nausea-vomiting was the most prevalent adverse event after NACT, followed by neutropenia (11.66%), diarrhea (8.33%), and anemia (up to 3.33%). Thus, we conclude that, during the 6-month follow-up, we found no disease recurrence. The buccal-alveolar complex was also affected in several patients. The utilization of induction CT in cases of T4b unresectable cancer has been found to slow disease development, yield a partial macroscopic response, and be safe and feasible. This strategy should increase survival rates for patients who have surgery.