Isaacs’ Syndrome (Acquired Neuromyotonia): A Case Report

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Case Report | | Volume 9 Issue 1 (July-September, 2020) | Pages 2 - 3

Isaacs’ Syndrome (Acquired Neuromyotonia): A Case Report

Salman Mansoor

Salman Assad

Hamza Hassan Khan

Shoab Saadat

Department of Neurology, Cork University Hospital, Cork, Ireland

Shifa College of Medicine, Islamabad, Pakistan

Department of Nephrology, Portsmouth N.H.S Trust Queen Alexandra Hospital, Portsmouth, United Kingdom

Under a Creative Commons license

Open Access

Received

Oct. 15, 2017

Accepted

June 6, 2020

Published

June 30, 2020

Abstract

We report a case of a 24-year-old male, laborer by profession, who consulted neurology outpatient with chronic symptoms of gross muscle contractions, generalized weakness, and limitation in his routine activities since the age of eight. The examination was remarkable for pseudo hypertrophy in the calves muscles, pes cavus, and gross spontaneous muscle fasciculation with symmetrical involvement of the distal and proximal muscle groups in lower and upper extremities. His creatinine phosphate kinase (CPK) levels in blood were high. Nerve conduction study (NCS) and electromyography (EMG) confirmed diagnosis of Issacs’ disease showing neuromyotonic discharges associated with denervation and polyphasic units with fibrillation, positive sharp waves, and continuous repetitive discharges. He was started on carbamazepine, to which he responded well, and his symptoms improved.

Keywords

Neuromyotonia; Issacs’ Syndrome; Pakistan