Laparoscopic Release of the Median Arcuate Ligament: A Case Series and Review of Literature

Median Arcuate Ligament Syndrome (MALS), also known as celiac artery compression syndrome or Dunbar syndrome, is a rare vascular disorder characterised by extrinsic compression of the celiac trunk by the median arcuate ligament—a fibrous arch that connects the diaphragmatic crura across the aortic hiatus. Although the median arcuate ligament anatomically compresses the celiac artery in up to 10–24% of the population, only a minority develop clinical symptoms, suggesting a complex interplay of anatomical and neurogenic factors in the pathogenesis of MALS [1-3].

The classical clinical triad of MALS includes postprandial epigastric pain, significant weight loss, and an abdominal bruit. However, many patients present with non-specific or vague upper abdominal symptoms such as nausea, early satiety, bloating, or intermittent vomiting—leading to diagnostic uncertainty and frequent misdiagnosis as functional gastrointestinal disorders, peptic ulcer disease, or psychosomatic complaints [4,5]. The variability in symptomatology and absence of disease-specific biomarkers contribute to significant delays in diagnosis, often resulting in chronic debilitation and impaired quality of life.

Diagnosis of MALS is fundamentally reliant on a combination of clinical suspicion and radiological confirmation. Doppler ultrasound is a non-invasive and commonly used first-line modality that demonstrates elevated peak systolic velocities (>200 cm/s) in the celiac axis, particularly during expiration. However, due to operator dependency and variability with respiration, computed tomography angiography (CTA) or magnetic resonance angiography (MRA) is often required for anatomical confirmation. Classic findings include a focal narrowing of the proximal celiac axis with a characteristic “hooked” appearance on sagittal reconstructions, exacerbated during expiration, and post-stenotic dilatation of the artery [6,7]. Recent studies have emphasized the utility of dynamic imaging protocols and three-dimensional reconstructions for accurate assessment of celiac artery compression and collateral circulation.

The pathophysiology of MALS remains multifactorial. Beyond mechanical compression of the celiac trunk leading to mesenteric ischemia, some researchers propose a neurogenic component involving irritation or entrapment of the celiac plexus fibers by the median arcuate ligament, contributing to the visceral pain and autonomic symptoms observed in many patients [8]. This neurovascular hypothesis underpins the rationale for surgical decompression that includes not only ligament division but also celiac ganglionectomy.

Historically, open surgical release of the median arcuate ligament was the standard of care. However, since the early 2000s, laparoscopic techniques have gained favor due to their minimally invasive nature, improved visualization of the operative field, reduced postoperative pain, shorter hospital stay, and quicker return to normal activity [9-11]. The laparoscopic approach facilitates precise dissection of the crura and surrounding fibrotic tissue from the celiac artery with minimal morbidity. Several studies have reported success rates exceeding 70–80% for symptom resolution following laparoscopic decompression, especially in carefully selected patients [12-14]. Nevertheless, the variability in operative technique, inconsistent use of adjunctive intraoperative vascular imaging, and lack of long-term follow-up data continue to limit generalizability and standardization of this approach.

Despite a growing interest in laparoscopic management of MALS, published data remain limited to case reports and small series, with significant heterogeneity in patient selection, diagnostic protocols, and outcome measures. Given the rarity of the condition and diagnostic complexity, further surgical case series with structured methodology and follow-up are needed to contribute to the body of evidence.

The present case series aims to describe three consecutive patients with symptomatic MALS who underwent successful laparoscopic median arcuate ligament release at our tertiary care institution. We highlight diagnostic criteria, operative technique, perioperative outcomes, and symptom resolution in the postoperative period, providing insights into the role of minimally invasive surgery in this complex vascular syndrome (Table 1).

Table 1: Case Presentations

Pre-operative Duplex USG image of Case 3 showing peak systolic velocity of 128 cm/sec at the celiac axis (Figure 1).

Figure 1: Pre-Operative Duplex USG Images

In Case 3, CT-angiography performed in the arterial phase (sagittal section) demonstrated significant vascular compression. The celiac artery appeared narrowed at its origin with post-stenotic dilatation, while the superior mesenteric artery (SMA) showed a decreased aorto-mesenteric angle, indicating additional vascular involvement (Figure 2).

Figure 2: CT-Angiography images

In the venous phase sagittal CT-angiography of Case 3, the left renal vein was seen compressed, consistent with nutcracker morphology. In addition, the third part of the duodenum was compressed, a finding suggestive of superior mesenteric artery (SMA) syndrome. These observations highlight the presence of multiple vascular compressive features in the same patient (Figure 3).

Figure 3: Venous phase CT (sagittal) of Case 3 showing compressed left renal vein (nutcracker morphology) and compression of the third part of the duodenum (SMA syndrome)

Figure 4 demonstrates the arterial phase axial CT of Case 3, highlighting compression of the celiac artery (C). The adjacent common hepatic artery (A) and splenic artery (B) are also clearly visualized. This vascular compression may suggest underlying anatomical variations or external compressive factors, which could have clinical implications such as compromised blood flow to the upper abdominal organs. The image emphasizes the importance of careful assessment of celiac artery morphology in patients presenting with relevant symptoms.

Figure 4: Arterial phase CT (axial) of Case 3 showing compressed celiac artery (C) with adjacent common hepatic artery (A) and splenic artery (B)

Figure 5 illustrates the vascular compression in Case 3, where the superior mesenteric artery (SMA) exerts pressure on the left renal vein, as seen on the arterial phase (A). The venous phase image (B) reveals pre-stenotic dilatation proximal to the site of compression, indicating impaired venous outflow. These findings are characteristic of nutcracker phenomenon and highlight the significance of multiphasic CT imaging in evaluating vascular compression syndromes.

Figure 5: Arterial (A) and venous (B) phase CT images of Case 3

In all the three cases we have done thorough diagnoastic laparoscopy to rule out any gross pathologies. Further, left lobe of the liver is retracted, exposing the hepatogastric ligament (Figure 6).

Figure 6: Operative steps showing (A) port placement and (B) diagnostic laparoscopy with access to the lesser sac

The Pars Flaccida part of the ligament is fanned out and divided using a harmonic scalpel to gain access to the lesser sac.

Figure 7 demonstrates the identification of the left gastric artery (A) during surgery. Upon entering the lesser sac, the left gastric artery was the first vessel encountered and was carefully traced caudally to delineate the trifurcation of the celiac axis. This step is crucial for safe dissection and proper vascular orientation during the procedure.

Figure 7: Identification of Left Gastric artery

Figure 8 illustrates the celiac artery trifurcation, known as the “Mercedes Benz sign,” with the left gastric artery (B), common hepatic artery (A), and splenic artery (C) clearly identified. The thick fibrous portion of the median arcuate ligament (*) was observed overlying the celiac artery, suggesting external compression at this site. Careful identification of these vascular structures is essential to assess and manage potential celiac artery entrapment.

Figure 8: Identification of celiac artery trifurcation (“Mercedes Benz sign”) with left gastric artery (B), common hepatic artery (A), and splenic artery (C); thick fibrous median arcuate ligament (*) noted

Figure 9 highlights the dissection at the point marked ☆, where the fibers of the median arcuate ligament were completely divided to expose the celiac artery. The visible arterial pulsations at this site indicate successful release of the ligament and restoration of unobstructed blood flow.

Figure 9: Dissection at the point marked (☆) showing complete division of the median arcuate ligament fibers and exposure of the celiac axis with visible arterial pulsations

After releasing the compression over the celiac artery, the ligament is further divided more cranially towards the hiatus, approximately 5 cm. This plane of dissection is very close to the wall of the Abdominal Aorta, which requires meticulous precision to carry out this maneuver (Figure 10).

Figure 10: Celiac artery (C) exposed after cranial division of the median arcuate ligament (*) with adjacent abdominal aorta (A)

Utmost care must be taken not to injure the aorta which could lead to adverse outcomes. The image above shows the celiac artery arising from the aorta, abdominal complete being stripped off of the MAL and exposed, both the cut end of the ligament could be appreciated.

A total of three patients (2 male, 1 female; mean age 28.3 years) underwent laparoscopic median arcuate ligament release for symptomatic MALS at our institution. All the three procedures were done by a well experienced laparoscopic surgeon in a tertiary care hospital. The mean duration of symptoms prior to diagnosis was 14 months (range: 9–22 months), and all patients presented with postprandial epigastric pain, weight loss (mean 7.2 kg), and functional impairment (Table 2). Preoperative imaging confirmed celiac artery compression and characteristic hook-shaped narrowing on CT angiography. All procedures were completed laparoscopically without the need for conversion to open surgery. The mean operative time was 100 minutes (range: 92–112 minutes), and estimated blood loss was minimal (<10 mL) in all cases. No intraoperative or immediate postoperative complications occurred. Conversion rate was nill. Patients resumed oral intake on postoperative day one and were discharged within 2–3 days. At a short follow up of 3months, all three patients reported complete symptom improvement. No reinterventions were required. Postoperative duplex ultrasound confirmed adequate celiac artery flow, with a peak systolic velocity of 63 cm/s, indicating successful decompression (Figure 11).