The Effect of Some Biochemical Parameters in Children with Jaundice

Objective: This study aims to evaluate the biochemical parameters associated with jaundice in children and to examine their relationship with liver functions in order to determine their role in the early diagnosis of the disease. Methods: One hundred blood samples were collected from children with jaundice at the Children's Teaching Hospital in Karbala Governorate between January and February 2026, and serum was separated, after which biochemical tests were performed, including the measurement of total bilirubin and liver enzymes (ALT, AST). Results:  The results showed an increase in bilirubin levels in children with jaundice, as the mean total bilirubin (TB) level was 1.26 mg/dL, with a relative increase in liver enzymes, where the mean ALT = 22.09 U/L and the mean AST = 34.86 U/L. The results also showed a positive correlation between elevated bilirubin levels and enzyme levels, as the correlation value between AST and TB was (r = 0.334, P < 0.05), indicating an effect on liver function. In addition, a significant difference was observed in the incidence rate between males and females, with males accounting for 64% compared to 36% for females (P value = 0.045). Conclusion: The study indicates that biochemical parameters, particularly bilirubin and liver enzymes, are important indicators in the diagnosis of jaundice and the evaluation of its severity, and they contribute to making appropriate therapeutic decisions and reducing potential complications.